Avatrombopag

Avatrombopag, sold under the brand name Doptelet, is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure.[8][9] It was approved for medical use in the United States in May 2018,[10][11] the European Union in June 2019,[7] and Australia in January 2023.[1]

It acts as a thrombopoietin receptor agonist.[12]

References

  1. ^ a b c "Doptelet". Therapeutic Goods Administration (TGA). 30 January 2023. Archived from the original on 5 February 2023. Retrieved 8 April 2023.
  2. ^ "Doptelet (Swedish Orphan Biovitrum Pty Ltd)". Therapeutic Goods Administration (TGA). 16 February 2023. Archived from the original on 27 March 2023. Retrieved 8 April 2023.
  3. ^ "AusPAR: Doptelet". Therapeutic Goods Administration (TGA). 8 February 2024. Retrieved 31 March 2024.
  4. ^ "Details for: Doptelet". Health Canada. 22 January 2024. Archived from the original on 3 March 2024. Retrieved 3 March 2024.
  5. ^ "Notice: Multiple additions to the Prescription Drug List (PDL) [2023-12-22]". Health Canada. 22 December 2023. Archived from the original on 3 January 2024. Retrieved 3 January 2024.
  6. ^ "Doptelet- avatrombopag maleate tablet, film coated". DailyMed. 1 July 2021. Archived from the original on 3 March 2024. Retrieved 3 March 2024.
  7. ^ a b "Doptelet EPAR". European Medicines Agency (EMA). 24 April 2019. Archived from the original on 22 May 2020. Retrieved 2 May 2020.
  8. ^ Abdela J (2019). "Current Advance in Thrombopoietin Receptor Agonists in the Management of Thrombocytopenia Associated With Chronic Liver Disease: Focus on Avatrombopag". Clinical Medicine Insights. Blood Disorders. 12: 1179545X19875105. doi:10.1177/1179545X19875105. PMC 6804364. PMID 31673229.
  9. ^ Markham A (November 2021). "Avatrombopag: A Review in Thrombocytopenia". Drugs. 81 (16): 1905–1913. doi:10.1007/s40265-021-01613-y. PMC 8610948. PMID 34709601.
  10. ^ "FDA approves new drug for patients with chronic liver disease who have low blood platelets and are undergoing a medical procedure". U.S. Food and Drug Administration (FDA) (Press release). 21 May 2018. Archived from the original on 11 December 2019. Retrieved 2 May 2020.
  11. ^ "Drug Approval Package: Doptelet (avatrombopag)". U.S. Food and Drug Administration (FDA). 28 June 2018. Archived from the original on 7 April 2021. Retrieved 2 May 2020.
  12. ^ Kuter DJ (November 2021). "The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag". Blood Reviews. 53: 100909. doi:10.1016/j.blre.2021.100909. PMID 34815110. S2CID 244285488.