Injury

A crabeater seal injured by a predator

Injury is physiological damage to the living tissue of any organism, whether in humans, in other animals, or in plants.

Injuries can be caused in many ways, such as mechanically with penetration by sharp objects such as teeth or with blunt objects, by heat or cold, or by venoms and biotoxins. Injury prompts an inflammatory response in many taxa of animals; this prompts wound healing. In both plants and animals, substances are often released to help to occlude the wound, limiting loss of fluids and the entry of pathogens such as bacteria. Many organisms secrete antimicrobial chemicals which limit wound infection; in addition, animals have a variety of immune responses for the same purpose. Both plants and animals have regrowth mechanisms which may result in complete or partial healing over the injury. Cells too can repair damage to a certain degree.

Taxonomic range

Animals

A sand lizard that has shed its tail when attacked by a predator, and has started to regrow a tail from the site of the injury

Injury in animals is sometimes defined as mechanical damage to anatomical structure,[1] but it has a wider connotation of physical damage with any cause, including drowning, burns, and poisoning.[2] Such damage may result from attempted predation, territorial fights, falls, and abiotic factors.[2]

Injury prompts an inflammatory response in animals of many different phyla;[3] this prompts coagulation of the blood or body fluid,[4] followed by wound healing, which may be rapid, as in the cnidaria.[3] Arthropods are able to repair injuries to the cuticle that forms their exoskeleton to some extent.[5]

Animals in several phyla, including annelids, arthropods, cnidaria, molluscs, nematodes, and vertebrates are able to produce antimicrobial peptides to fight off infection following an injury.[1]

Humans

Injuries to humans elicit an elaborate response including emergency medicine, trauma surgery (illustrated), and pain management.

Injury in humans has been studied extensively for its importance in medicine. Much of medical practice, including emergency medicine and pain management, is dedicated to the treatment of injuries.[6][7] The World Health Organization has developed a classification of injuries in humans by categories including mechanism, objects/substances producing injury, place of occurrence, activity when injured and the role of human intent.[8] Injuries can cause psychological harm including post-traumatic stress disorder in addition to physical harm.[9]

Plants

Oak tree split by lightning, an abiotic cause of injury.

In plants, injuries result from the eating of plant parts by herbivorous animals including insects and mammals,[10] from damage to tissues by plant pathogens such as bacteria and fungi, which may gain entry after herbivore damage or in other ways,[11] and from abiotic factors such as heat,[12] freezing,[13] flooding,[14] lightning,[15] and pollutants[16] such as ozone.[17] Plants respond to injury by signalling that damage has occurred,[18] by secreting materials to seal off the damaged area,[19] by producing antimicrobial chemicals,[20][21] and in woody plants by regrowing over wounds.[22][23][24]

Cell injury

Cell injury is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. Cell damage can be reversible or irreversible. Depending on the extent of injury, the cellular response may be adaptive and where possible, homeostasis is restored.[25] Cell death occurs when the severity of the injury exceeds the cell's ability to repair itself.[26] Cell death is relative to both the length of exposure to a harmful stimulus and the severity of the damage caused.[25]

References

  1. ^ a b Rennolds, Corey W.; Bely, Alexandra E. (29 September 2022). "Integrative biology of injury in animals". Biological Reviews. 98 (1): 34–62. doi:10.1111/brv.12894. ISSN 1464-7931. PMC 10087827. PMID 36176189.
  2. ^ a b de Ramirez, Sarah Stewart; Hyder, Adnan A.; Herbert, Hadley K.; Stevens, Kent (2012). "Unintentional injuries: magnitude, prevention, and control". Annual Review of Public Health. 33: 175–191. doi:10.1146/annurev-publhealth-031811-124558. ISSN 1545-2093. PMID 22224893.
  3. ^ a b Sparks, Albert (1972). Invertebrate Pathology Noncommunicable Diseases. Academic Press. pp. 20, 133. ISBN 9780323151962.
  4. ^ Cerenius, Lage; Söderhäll, Kenneth (6 November 2010). "Coagulation in Invertebrates". Journal of Innate Immunity. 3 (1): 3–8. doi:10.1159/000322066. ISSN 1662-811X. PMID 21051883. S2CID 20798250.
  5. ^ Parle, Eoin; Dirks, Jan-Henning; Taylor, David (2016). "Bridging the gap: wound healing in insects restores mechanical strength by targeted cuticle deposition". Journal of the Royal Society Interface. 13 (117): 20150984. doi:10.1098/rsif.2015.0984. ISSN 1742-5689. PMC 4874426. PMID 27053653.
  6. ^ Maerz, Linda L.; Davis, Kimberly A.; Rosenbaum, Stanley H. (2009). "Trauma". International Anesthesiology Clinics. 47 (1): 25–36. doi:10.1097/AIA.0b013e3181950030. ISSN 1537-1913. PMID 19131750. S2CID 220567282.
  7. ^ Ahmadi, Alireza; Bazargan-Hejazi, Shahrzad; Heidari Zadie, Zahra; et al. (2016). "Pain management in trauma: A review study". Journal of Injury and Violence Research. 8 (2): 89–98. doi:10.5249/jivr.v8i2.707. ISSN 2008-4072. PMC 4967367. PMID 27414816.
  8. ^ "International Classification of External Causes of Injury (ICECI)". World Health Organization. Archived from the original on 17 October 2004. Retrieved 22 September 2023.
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