RNF11
RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[5][6][7]
Function
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[7]
See also
Interactions
RNF11 has been shown to interact with RIPK1[8] and STAMBP.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000123091 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028557 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (December 1999). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta. 1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045.
- ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
- ^ a b "Entrez Gene: RNF11 ring finger protein 11".
- ^ Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965.
- ^ Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.
Further reading
- Burger A, Amemiya Y, Kitching R, Seth AK (2006). "Novel RING E3 ubiquitin ligases in breast cancer". Neoplasia. 8 (8): 689–95. doi:10.1593/neo.06469. PMC 1601945. PMID 16925951.
- Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
- Watanabe T, Ichihara M, Hashimoto M, Shimono K, Shimoyama Y, Nagasaka T, Murakumo Y, Murakami H, Sugiura H, Iwata H, Ishiguro N, Takahashi M (2002). "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation". Am. J. Pathol. 161 (1): 249–56. doi:10.1016/S0002-9440(10)64176-4. PMC 1850689. PMID 12107109.
- Kitching R, Wong MJ, Koehler D, Burger AM, Landberg G, Gish G, Seth A (2003). "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases". Biochim. Biophys. Acta. 1639 (2): 104–12. doi:10.1016/j.bbadis.2003.07.001. PMID 14559117.
- Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase". Br. J. Cancer. 89 (8): 1538–44. doi:10.1038/sj.bjc.6601301. PMC 2394340. PMID 14562029.
- Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.
- Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Connor MK, Azmi PB, Subramaniam V, Li H, Seth A (2005). "Molecular characterization of ring finger protein 11". Mol. Cancer Res. 3 (8): 453–61. doi:10.11580ooo4te>6">10maneo >://en e2sMCR-0ba >Mol. Cu/erNN 3–6laNMo>p>eo >a>:N 3�e>a>:0d/ex>n920elateSty>:0d1etion of rivs:r1920Stytd1eN 3�e>a>:0d/etd1eN 3�e>a>:0d/etite>6isucHN-/exe r1920p04-0idb">a>b"lnmptuubra"l1normpanmptui h8Ci(ruI920e">doiHsucHN-itee "lnmppp>eoidb"mpab"lnmpap