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Medical Education British Journal of Ophthalmology current issue

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British Journal of Ophthalmology current issue - Recent Educational Updates

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At a glance
<sec id="s1"><st>Characterisation of ectasia after penetrating keratoplasty in keratoconus eyes using anterior-segment optical coherence tomography (<I>see page 506</I>)</st> <p>Optical coherence tomography can be used to image corneal ectasia which occurs late following penetrating keratoplasty. Corneas with late post-keratoplasty ectasia have a deeper anterior chamber, steeper graft-host interface angle, and lower thickness at the interface</p> </sec> <sec id="s2"><st>Crystalline lens nuclear age prediction as a new biomarker of nucleus degeneration (<I>see page 513</I>)</st> <p>A deep learning algorithm was developed to predict nuclear age, which provides insight into the premature ageing of the lens nucleus. Findings also suggest that nuclear age could serve as an indirect marker for nuclear cataract.</p> </sec> <sec id="s3"><st>Adduction induces large optic nerve head deformations in subjects with normal tension glaucoma (<I>see page 522</I>)</st> <p>Adduction movement was found to induce large strains in the optic nerve head. Higher strain, especially at the lamina cribrosa, associated with adduction was...


Pan-Indian multicentre retrospective study of 0.01% atropine for myopia control
<p>The recent publication by Rohit <I>et al</I> evaluated the efficacy of 0.01% atropine in controlling myopia progression among Indian children over a 2-year period.<cross-ref type="bib" refid="R1">1</cross-ref> A total of 732 myopic children aged 6&ndash;14 years from 20 centres were included, and all received 0.01% atropine eye-drops once daily. The authors found that, during the first year, there was a relative reduction of 64% in myopia progression, and during the second year, the efficacy was 11% more, as compared with the first year. Furthermore, individual treatment response was found to be associated with age and initial myopia severity, with a weaker effect in younger children and in children with higher baseline myopia.</p> <p>The main strength of this study was that the patients were recruited from 20 centres located across various regions all over India. Thus, this Pan-India study design can potentially reflect the efficacy of low-concentration atropine on India children....


Stargardt macular dystrophy and therapeutic approaches
<p>Stargardt macular dystrophy (Stargardt disease; STGD1; OMIM 248200) is the most prevalent inherited macular dystrophy. STGD1 is an autosomal recessive disorder caused by multiple pathogenic sequence variants in the large <I>ABCA4</I> gene (OMIM 601691). Major advances in understanding both the clinical and molecular features, as well as the underlying pathophysiology, have culminated in many completed, ongoing and planned human clinical trials of novel therapies.</p> <p>The aims of this concise review are to describe (1) the detailed phenotypic and genotypic characteristics of the disease, multimodal imaging findings, natural history of the disease, and pathogenesis, (2) the multiple avenues of research and therapeutic intervention, including pharmacological, cellular therapies and diverse types of genetic therapies that have either been investigated or are under investigation and (3) the exciting novel therapeutic approaches on the translational horizon that aim to treat STGD1 by replacing the entire 6.8 kb <I>ABCA4</I> open reading frame.</p>


Characterisation of ectasia after penetrating keratoplasty in keratoconus eyes using anterior segment optical coherence tomography
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