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MedPage Today Rheumatology - Recent Educational Updates

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Truly Novel RA Drug Passes Mid-Stage Test
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115171.jpg"/> (MedPage Today) -- Combining the Janus kinase (JAK) inhibitor tofacitinib (Xeljanz) with an investigational oral drug targeting a different type of kinase enzyme was more effective against rheumatoid arthritis (RA) than tofacitinib alone in a phase...


Registry Data Reassure on JAK Inhibitors' Heart Risks
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115129.jpg"/> (MedPage Today) -- Suggestions that rheumatoid arthritis (RA) patients suffer more cardiovascular events when treated with Janus kinase (JAK) inhibitors compared with tumor necrosis factor (TNF) blockers or other biologic drugs were not borne out...


Study: Increased Heart Risk Isn't a Given in Rheumatoid Arthritis
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115052.jpg"/> (MedPage Today) -- Rheumatoid arthritis (RA) patients face very different risks for cardiovascular disease and events depending on their body mass index (BMI), use of biologic drugs for RA, and, crucially, whether they carry anti-citrullinated...


Randomized Trial Tests Yoga as Knee Osteoarthritis Therapy
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115010.jpg"/> (MedPage Today) -- Patients with osteoarthritis (OA) of the knee got at least as much benefit from yoga as from conventional strength training in a randomized trial, researchers said. Pain was reduced about equally with yoga and strength training...


Do This When Stopping Adalimumab in Pediatric Eye Disease
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114962.jpg"/> (MedPage Today) -- Patients with pediatric non-infectious uveitis (NIU) who achieved remission on adalimumab (Humira) had lower recurrence rates when the drug was withdrawn more gradually, a retrospective cohort analysis indicated. Recurrence...


Study: Treat Adult-Onset Still's Disease With Biologics
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114954.jpg"/> (MedPage Today) -- Patients with adult-onset Still's disease were much more likely to achieve sustained remission when they were initially treated with biologic agents than corticosteroids or conventional disease-modifying anti-rheumatic drugs...


Metals From Joint Implants Appear to Be Leaking Into CSF
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114877.jpg"/> (MedPage Today) -- Patients with metal-containing joint replacements had significantly higher concentrations of cobalt in their cerebrospinal fluid (CSF) relative to patients without arthroplasties, researchers reported. Although CSF in both groups...


This Biomarker Predicts Very Long-Term JIA Outcomes
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114788.jpg"/> (MedPage Today) -- Patients with juvenile idiopathic arthritis (JIA) who carried the HLA-B27 genetic marker tended to have worse long-term outcomes, including lower rates of drug-free remission, in a prospective Scandinavian study. Among 434 patients...


Newer Biologics Tied to Fewer Infections for Older Patients With Psoriatic Disease
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114768.jpg"/> (MedPage Today) -- Biologics targeting interleukin (IL)-12, IL-23, and IL-17 were associated with a lower rate of serious infections among older adults with psoriatic disease, a Canadian cohort study showed. For more than 11,000 older adults started...


Will Medicare Price Negotiations Really Cut Rheum Drug Costs?
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114759.jpg"/> (MedPage Today) -- Negotiations to set prices Medicare will pay for the original branded version of etanercept, Enbrel, should bring the government some genuine savings, and may indirectly make it more affordable for everyone, a new analysis indicated...


CDC Division in Jeopardy; RFK Jr. Silent on Mercury; What Works for Low Back Pain?
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114725.jpg"/> (MedPage Today) -- Note that some links may require registration or subscription. MedPage Today is collecting stories of HHS staffers across all agencies affected by Trump administration cuts. If you want to share your story, please email MPT_Editorial...


Routine Adrenal Insufficiency Screening: Not Needed After Steroid Cessation?
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114710.jpg"/> (MedPage Today) -- Glucocorticoid-induced adrenal insufficiency (GIAI) may be less common than previously expected, a Danish cross-sectional study indicated. Out of 267 patients with polymyalgia rheumatica or giant cell arteritis who stopped prednisolone...


TYK2 Inhibitor Scores Two Wins Outside Plaque Psoriasis
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114579.jpg"/> (MedPage Today) -- ORLANDO -- The TYK2 inhibitor deucravacitinib (Sotyktu) showed clinical potential in two diseases other than psoriasis, according to studies reported here. More than half of patients with psoriatic arthritis (PsA) had at least...


Five Things Patients With Low Back Pain Need From Their Doctors
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114573.jpg"/> (MedPage Today) -- Hopelessness. Fear. Isolation. These are the feelings reflected in the stories we heard from people living with low back pain (LBP) who participated in two focus groups held by the Duke Clinical Research Institute. These patients...


Long-Term Use of NSAIDs Linked to Lower Dementia Risk
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114555.jpg"/> (MedPage Today) -- Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) was tied to a decreased risk of dementia, data from the prospective Rotterdam Study showed. Over an average follow-up of 14.5 years, use of NSAIDs for 24 months...


Steroid Shots for OA Helpful Well Beyond 3 Months
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114470.jpg"/> (MedPage Today) -- British patients with osteoarthritis (OA) who received intra-articular corticosteroid injections had less usage of opioid-containing drugs and other painkillers for years afterward, researchers said. Over the 5 years following...


Off-the-Shelf Drugs May Treat This New Autoimmune Disease
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114440.jpg"/> (MedPage Today) -- Janus kinase (JAK) inhibitors look to be a good treatment option for the newly recognized, rare autoimmune disease known as SOCS1 insufficiency, researchers found. Which was not exactly a surprise. SOCS1 stands for "suppressor...


Frequent Healthcare Visits Seen as Early Flag for Lupus
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114417.jpg"/> (MedPage Today) -- In the years preceding diagnosis of systemic lupus erythematosus (SLE), Danish patients saw healthcare providers at about triple the rate of individuals without lupus, researchers found. Comparing 2,022 lupus patients with 20...


Ankle Fusion or Total Replacement? This Study May Help You Decide
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114369.jpg"/> (MedPage Today) -- In a large study of British patients needing surgical treatment for advanced arthritis in the ankle, fusion appeared to be a better option than total ankle replacement. Among some 10,000 patients undergoing total ankle replacement...


Here's How Patients With Obesity Can Avoid Joint Replacement Revision
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114300.jpg"/> (MedPage Today) -- British patients with obesity undergoing hip and knee replacements had less of a need for subsequent revision when, after surgery, they lost weight by using medications such as GLP-1 receptor agonists, a cohort study showed...


Another Expert Group Throws Shade at Spinal Injections for Back Pain
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114277.jpg"/> (MedPage Today) -- Just a week after an American Academy of Neurology (AAN) committee found "limited efficacy" for epidural steroid injections to treat chronic back pain, an international panel is going much further, calling for an end to these...