An one-stop career platform detailing Schools & Universities offering English language, Bachelor, Master and PhD programs with course fee, living cost, scholarships, visa details, etc.
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Cyprus College
cycollege.ac.cy
The college was founded in 1961 with the purpose to provide a well rounded education of high calibre where students can acquire the necessary academic knowledge.
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Wroclaw University
international.uni.wroc.pl
Founded in 1702 by Leopold I Habsburg. Since the beginning of 20th century the university has produced 9 Nobel Prize winners.
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Volyn University
vdu.edu.ua
The history dates back to 1940. At present, the university includes 4 institutes, 14 faculties and 73 departments.
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Berkeley College
berkeleycollege.edu
Through the power of internet, Berkeley college online brings the classroom to you anywhere in the world with the same high level of support as On-Campus classes.
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AIS
ais.ac.nz
New Zealand's largest international degree provider. The programmes are focused on the global marketplace.
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<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Aims</div>Despite increasing prevalence, the general population lacks knowledge regarding diagnosis, implications, and management of cardiac arrhythmias (CA). This study aims to assess public perception of CA and identify knowledge gaps.<div class="boxTitle">Methods and results</div>The 36-item <span style="font-style:italic;">PULSE</span> survey was disseminated via social media to the general population and conducted under the auspices of the European Heart Rhythm Association Scientific Initiatives Committee (EHRA SIC) with EHRA patient committee support. Among 3924 participants (2177 healthy, 1747 with previously diagnosed CA; 59% female, 90% European), 81% reported fear of CA. Females were more likely to be ‘very’ or ‘moderately afraid’ than males [odds ratio (OR) 1.159 (1.005, 1.337), <span style="font-style:italic;">P</span> = 0.046]. While most recognized complications of CA—heart failure (82%), stroke (80%), and death (75%)—43% were unaware that CA can be asymptomatic. Those with cardiopulmonary resuscitation (CPR) training in the past 5 years were 2.6 times and 4.7 times more confident identifying sudden cardiac death and initiating CPR (<span style="font-style:italic;">P</span> < 0.001). Confidence was lower in retired participants [OR 0.574 (0.499, 0.660), <span style="font-style:italic;">P</span> < 0.001] and Southern Europeans [OR 0.703 (0.600, 0.824), <span style="font-style:italic;">P</span> < 0.001]. Without CPR training, only 15% felt confident initiating CPR. Among CA participants, 28% reported severe to disabling daily symptoms. Males were more often asymptomatic (20% vs. 9%, <span style="font-style:italic;">P</span> < 0.001). Treatment rates were comparable between sex categories (81% vs. 79%, <span style="font-style:italic;">P</span> = 0.413). Interdisciplinary shared decision-making processes were reported by 4%. Notably, 1 in 10 CA cases was self-diagnosed using a wearable device, and 30% of CA participants used smartwatches for self-monitoring.<div class="boxTitle">Conclusion</div>Significant knowledge gaps regarding CA exist in the general population. Targeted educational initiatives could be a viable tool to enhance public knowledge, confidence in detecting and managing arrhythmias, particularly for women, who experience greater fear and symptom severity despite similar treatment rates.</span>
<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Aims</div>We studied the blood pressure (BP) decrease after carotid sinus massage to study cardioinhibition (CI) and arterial vasodepression (aVD), whether CI and aVD occur independent of one another, and how the BP decrease ends.<div class="boxTitle">Methods and results</div>We measured BP, heart rate (HR), stroke volume, and total peripheral resistance (TPR) retrospectively in carotid sinus massage cohorts in two Dutch syncope centres. Cardioinhibition and aVD were defined as HR and TPR decreasing below 3 SD under pre-massage baseline means. We used the logratio method to analyse changes relative to baseline and tested whether CI and aVD occurred together more often than through chance and whether the responses depended on massage duration and on corrective BP increases. Cardioinhibition occurred in 48% and aVD in 30% of 244 massages of 90 persons. Cardioinhibition and aVD did not occur together more often than randomly. Compared with aVD, CI occurred more often, earlier, faster, and shorter with a larger maximal but similar overall BP-decreasing effect. Longer massage duration yielded a larger BP decrease through stronger aVD. The BP decrease evoked corrective increases of HR and TPR.<div class="boxTitle">Conclusion</div>Cardioinhibition appears as a phasic response to the onset of massage, independent of aVD, which is a more latent response sensitive to ongoing massage. Blood pressure corrections probably depend on the contralateral carotid sinus and aortic baroreceptors. The BP decrease after sinus massage may in part depend on the efficacy of corrective responses.</span>
<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Aims</div>Adherence to an ideal cardiovascular health (CVH) might contribute to lower the burden of sudden cardiac death (SCD) in the community. We aimed to examine the association between the number of ideal CVH metrics at baseline and of its change over 10 years with the risk of SCD.<div class="boxTitle">Methods and results</div>The Copenhagen City Heart Study is a community-based prospective cohort study. The number of ideal CVH metrics (range 0–6; non-smoking and ideal level of body mass index, physical activity, untreated glucose, untreated systolic blood pressure, and untreated total cholesterol levels) at baseline in 1991–94 and its 10-year change thereof between 1981–83 and 1991–94 were evaluated. Definite SCD was defined as a death occurring within 1 h (eye-witnessed case) or within 24 h (non-eye–witnessed) of symptoms onset, with the presence of confirmed ventricular tachycardia and the exclusion of non-cardiac cause at autopsy. Fine and Gray sub-distribution HRs (sHRs) were calculated to account for competing risk. The study population includes 8837 participants (57% women; mean age 57 years, ±15 years) in 1991–94. After a median follow-up of 22.6 years from 1 January 1993 up to 31 December 2016, 56 definite SCD occurred. The risk of definite SCD decreased gradually with the number of ideal metrics in 1991–94 [sHR = 0.58; 95% confidence interval (CI): 0.44–0.75 per additional ideal metric] and with the change (i.e. improvement) in the number of ideal metrics between 1981–83 and 1991–94 (sHR = 0.68; 0.50–0.93 per change in the number of ideal metrics). Effect size was lower for coronary death, all-cause mortality, and coronary heart disease events.<div class="boxTitle">Conclusion</div>Adherence to a higher number of ideal cardiovascular health was related to a substantial lower risk of definite SCD.</span>
<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Aims</div>Advanced technologies such as charge density mapping (CDM) show promise in guiding adjuvant ablation in patients with persistent atrial fibrillation (AF); however, their limited availability restricts widespread adoption. We sought to determine whether regions of the left atrium containing CDM-identified pivoting and rotational propagation patterns during AF could also be reliably identified using more conventional contact mapping techniques.<div class="boxTitle">Methods and results</div>Twenty-two patients undergoing <span style="font-style:italic;">de novo</span> ablation of persistent AF underwent both CDM and electroanatomic voltage mapping during AF and sinus rhythm with multiple pacing protocols. Through the use of a left atrium statistical shape model, the location of distinctive propagation patterns identified by CDM was compared with low-voltage areas (LVAs) and regions of slow conduction velocity (CV). Neither LVA nor CV mapping during paced rhythms reliably identified regions containing CDM propagation patterns. Conduction velocity mapping during AF did correlate with these regions (ρ = −0.63, <span style="font-style:italic;">P</span> < 0.0001 for pivoting patterns; ρ = −0.54, <span style="font-style:italic;">P</span> < 0.0001 for rotational patterns). These propagation patterns consistently occurred in two specific anatomical regions across patients: the anteroseptal and inferoposterior walls of the left atrium.<div class="boxTitle">Conclusion</div>Mapping techniques during paced rhythms do not reliably correspond with regions of CDM-identified propagation patterns in persistent AF. However, these propagation patterns are consistently observed in two specific anatomical regions, suggesting a predisposition to abnormal electrophysiological properties. While further research is needed, these regions may serve as promising targets for empirical ablation, potentially reducing the reliance on complex mapping techniques.</span>
<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Aims</div>Genome-wide association studies (GWASs) identified common single-nucleotide polymorphisms (SNPs) in more than 100 genomic regions associated with atrial fibrillation (AF). We aimed to identify novel AF genes in Taiwanese population by multi-stage GWAS.<div class="boxTitle">Methods and results</div>In exploratory stage, we did GWAS with whole-genome genotypes (4 512 191 SNPs) in 516 patients with AF from the National Taiwan University AF Registry and 5160 normal sinus rhythm controls from the Taiwan Biobank. Significant loci were replicated in 1002 independent patients and 2003 controls and in the UK Biobank. Expression quantitative trait locus (eQTL) mapping and transcriptome-wide association study (TWAS) were performed to implicate functional significance. Stage I GWAS revealed three loci associated with AF with a genome-wide significance level, including one close to <span style="font-style:italic;">PITX2</span> gene (chromosome 4q25, rs2723329, minor allele frequency [MAF] 0.50 vs. 0.41, <span style="font-style:italic;">P</span> = 1.53 × 10<sup>−10</sup>), another close to <span style="font-style:italic;">RAP1A</span> gene (also to previous <span style="font-style:italic;">KCND3</span>; chromosome 1p13.2, rs7525578, MAF 0.17 vs. 0.07, <span style="font-style:italic;">P</span> = 1.24 × 10<sup>−26</sup>), and one novel locus close to <span style="font-style:italic;">HNF4G</span> gene (chromosome 8q21.13, rs2980218, MAF 0.44 vs. 0.35, <span style="font-style:italic;">P</span> = 2.19 × 10<sup>−9</sup>). They were validated in Stage II population. The eQTL analyses showed significant colocalization of 1p13.2 locus with <span style="font-style:italic;">RAP1A</span> gene expression in fibroblasts and 8q21.13 locus with <span style="font-style:italic;">HNF4G</span> expression in lymphocytes. There is a significant association of <span style="font-style:italic;">RAP1A</span> gene expression in fibroblasts and <span style="font-style:italic;">HNF4G</span> in lymphocytes and brain with AF in TWAS.<div class="boxTitle">Conclusion</div>Genome-wide association study in Taiwan revealed <span style="font-style:italic;">PITX2</span> and <span style="font-style:italic;">RAP1A/KCND3</span> loci and novel AF locus (<span style="font-style:italic;">HNF4G</span>) with the most significant locus in the <span style="font-style:italic;">RAP1A</span> locus. <span style="font-style:italic;">RAP1A</span> and <span style="font-style:italic;">HNF4G</span> genes may implicate fibrosis, metabolic, and neurogenic pathways in pathogenesis of AF.</span>
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